Nature has a remarkable knack for reproducing body and organ size within each species—essentially, your organs are proportionate to your body size. However, the tissue interactions and molecular signaling required to achieve this are not well understood.
As a 2025 Schmidt Science Fellow, Jake will combine novel approaches to measure cell behaviour when body size is perturbed and screen for the signals driving this regulation. This could provide us with the rules of size-control for the first time.
Jake’s research aims to create an atlas of interactions underpinning size control. This would have profound implications for controlling tissue growth in regeneration and cancer and for biomanufacturing transplant-ready human-sized organs.
Jake will pivot from Molecular & Cell Biology to Systems Biology