As a 2024 Schmidt Science Fellow, Sarah aims to study information transfer in DNA replication via state-of-the-art optical tweezers technology.
A single human genome can give rise to hundreds of cell types and tissues. This gene expression is specified by unique instructions written on the proteins that package DNA into chromosomes.
It is unknown how these instructions are specifically passed to daughter chromosomes during DNA replication. Understanding this mechanism could provide a blueprint for the development of novel therapeutics targeting cancer and regenerative medicine.