Many cycling technologies have been developed that allow multiplexed single cell profiling but current methods are very slow (~ 30 mins) and work with samples that can withstand harsh destaining/quenching conditions.

Researchers at Massachusetts General Hospital in Boston have developed an ultra-fast, gentle cycling method (< 1 sec) that can profile the immune landscape of tumor in an hour.

Dr. Jina Ko, 2018 Fellow, is first author on the paper. She commented: “This research was only possible by working across engineering and chemistry, and demonstrates the importance of interdisciplinary approaches.”

This cycling method could open new diagnostic possibilities for therapy monitoring to achieve the best possible treatment outcomes. Read more about Jina’s work with her colleagues in the Angewandte Chemie journal here.